Micky van de Ven Brace Ends The Toffees' Run at Brand New Stadium
Micky van de Ven emerged as the first defender to score two goals in a English top-flight game for Spurs since Jan Vertonghen in March 2013.
Key points
The Spurs defender heads into the net two times in opening period
Everton's Jake O'Brien has equalizer disallowed after VAR review
Pape Matar Sarr nets final goal in dying moments
This loss is the Merseyside club's first at Hill Dickinson Stadium
The Tottenham defender scored on two occasions as Spurs prolonged their unbeaten run in away games in the Premier League and delivered Everton their initial loss at their new home.
Everton were unbeaten in their last five matches at their new ground at the dockside location, having departed their historic home behind after more than a century at the end of last season.
But Tottenham's leader the Dutchman struck twice from set-pieces in the opening 45 minutes to put their impressive record at jeopardy, and they were failed to mount a comeback before Pape Matar Sarr - assisted by former Toffees attacker the Brazilian - headed home a third to put the game to bed.
Jake O'Brien believed he had equalized the tally five minutes after the defender's first goal, directing a bullet header past Guglielmo Vicario from an set-piece.
Beto, meanwhile, missed a number of opportunities, while the Italian goalkeeper made a series of fine saves to guarantee Tottenham went five matches on the road unbeaten in the Premier League.
But the video assistant referee intervened, instructing the match official to review the score on the pitchside monitor and the referee ruled that Jack Grealish and the attacker were in an illegal position and had interfered with the Spurs keeper.
This victory moves Thomas Frank's team up to third in the division, a handful of points off local foes and table-toppers Arsenal.
Everton remain 14th and sit half a dozen points ahead of the drop zone.
Tottenham analysis: The defender excels in duties at each end of pitch
After a uninspiring midweek performance in the Champions League against the French side, where they managed a only attempts on goal, Frank opted for Randal Kolo Muani in attack instead of ex-Everton forward Richarlison.
The new arrival was unable to make much of an impact before being replaced for the substitute after 60 minutes on the pitch, but it emerged he proved unnecessary in the final outcome.
Centre-back Van de Ven transformed into an attacking force to be feared.
Tottenham's opening strike came from a well-worked corner routine, with Rodrigo Bentancur directing the ball back across the face of goal for an unmarked the defender to head home.
And Ven de Ven - stepping up as skipper in Cristian Romero's unavailability - notched his next goal in added time as he outjumped Jordan Pickford to nod in.
The Dutchman was equally impressive in defensive duties, partnering well with Kevin Danso as the pair handled superbly with the numerous deliveries sent their way by the opposition.
Everton analysis: Toffees missing finishing touch
Everton's recent stadium had been a fortress, but it appears the freshness may have faded somewhat and supporters headed to the gates after the midfielder's third for Tottenham.
The break in Everton's unbeaten home run will not be a massive concern for David Moyes, but their striker situation are.
Beto and the other striker - the Everton's pair of recognised strikers - had scored just one league goal combined before the weekend's match.
And they were failed to contribute to that miserable record on a wet and gloomy night on Merseyside.
Beto's performance was epitomized when he chose to bicycle-kick a clear chance from near the goal, even with having space and time to reposition for a simpler shot that would have tested Vicario.
Barry, as well, failed to influence the game after coming on for Beto in the second half.
It wasn't for a shortage of chance. The majority of the home side's attacks came through Grealish and the forward, who tirelessly delivered dangerous balls into the Tottenham box.
Upcoming fixtures for these two sides?
Everton: The team head to Sunderland in the Premier League on early November at 8 PM.
Spurs: Spurs go to Newcastle's ground on Wednesday, 29 October for their fourth-round League Cup match against Newcastle.